Endocrine Abstracts

Background: GH deficiency has been reported widely in association with myelomeningocele and other pituitary hormone deficiencies occur less frequently. Following an episode of adrenal crisis in a newborn infant with myelomeningocele and multiple pituitary hormone deficiencies we introduced a policy of screening affected, newborn infants for pituitary insufficiency, focusing on thyroid function and cortisol levels.Patients and methods: Data from 26 infant...

Introduction: Achieving optimal levothyroxine replacement is more difficult in TSH deficiency compared to primary hypothyroidism because of the inability to be guided by TSH. A combination of clinical symptoms and free thyroxine levels (fT4) are typically used to monitor replacement. We reviewed adequacy of levothyroxine replacement in our patients with pituitary disease, and compared with fT4 levels in patients with primary thyroid disease.<p class="...

Phaeochromocytomas are neuroendocrine neoplasms originating from chromaffin cells of the adrenal medulla, causing 0.1–0.2% cases of hypertension. Although rare, phaeochromocytoma is potentially life-threatening, leading to hypertensive crises if unrecognised or mismanaged. Chronic thromboembolic pulmonary hypertension (CTEPH) is a potential complication of thromboembolic disease, usually resulting from ongoing vascular obstruction following pulmonary emboli. We report a c...

Introduction: Long-acting growth hormone (LaGH) therapy has emerged as a newer treatment option for children, with the potential to improve adherence and compliance. Clinical trials have shown LaGH formulations to be effective and safe in children with GH deficiency (GHD). Somatrogon (Ngenla) is licensed for use in children with GHD over than 3 years of age.Objective: We report the real-world experience of using once wee...

Objective: Higher obesity rates are related with increased non-alcoholic fatty liver disease (NAFLD) prevalence which may progress further to non-alcoholic steatohepatitis (NASH) and cirrhosis. The utility of Fibroscan was shown in stratifying risk for significant liver disease. The aim of the study was to evaluate the relation between body mass index (BMI) and liver stiffness measurements (LSM) in overweight and obese patients.Methods: We conducted the ...

Background: Acute pancreatitis is both a medical and surgical emergency. Common causes of acute pancreatitis include gallstones and alcohol. Hypertriglyceridemia-induced pancreatitis is rare (1-4%); here we discuss management of 5 cases of hypertriglyceridemia-induced pancreatitis.Case-1: 37-year-old female presented to A&E with epigastric pain radiating to back and vomiting. Blood test showed raised amylase, triglyceride 81.6 and cholesterol 6.1. CT...

The proto-oncogene pituitary tumor transforming gene binding factor (PTTG1IP/PBF) is overexpressed in multiple tumours and associated with tumour progression. One of the tumourigenic processes that PBF can mediate is cell motility. PBF can induce cell invasion in both thyroid and breast cancer cell lines. However, in contrast to wild-type (WT) PBF, the Y174A PBF mutant was not able to induce the invasiveness of thyroid or breast cancer cells. The Y174 residue is highly phospho...

Introduction: The incidence and prevalence of GEP-NENs is rising worldwide. NENs represent the group off well differentiated neuroendocrine tumours (NET) and poorly differentiated neuroendocrine carcinoma (NEC). NETs can be divided into grade 1 (G1), grade 2 (G2) and grade 3 (G3) based on histological parameters. There exist several studies regarding survival data but these are mainly based on national databases.Aim: To describe the real world overall su...

Background: People with chronic metabolic conditions such as type 2 diabetes (T2D) encounter challenges with self-management regimens to improve their glycemic control, weight and as well as to reduce complications associated with diabetes. Optimal management of T2D requires regular monitoring by physician, access to multidisciplinary care and achieving target HbA1c without hypoglycemia. Digital therapeutics (DTx) provide highly accessible, cost-effective, evidence-based solut...

By exploiting the canonical function of the sodium iodide symporter (NIS), ablative radioiodide therapy is an effective treatment for thyroid cancer. However, a subset of patients are unable to accumulate sufficient radioiodide due to decreased expression and/or plasma membrane localisation of NIS. Radioiodide therapy has been proposed as a viable treatment for breast cancer, but is hampered by low levels of NIS membrane localisation. Currently, the regulation of NIS trafficki...